In any case, people who take over the counter anti histamines experience weight gain. Possibly the same mechanism roughly is at work with the atypical antipsychotics. Except, as with the case of clozaril and zyprexa, where the histamine receptor 1 is blocked so heavily, and the weight comes on profusely, sometimes in some patients over one hundred pounds---this strong complete blocking of the histamine 1 receptor by the AAPs could just simply throw a switch, for the body to stay on fat utilization. Since the histamine 1 receptor metabolism and subsequent free fatty acid and lipid metabolism has gotten deranged. Clozaril and zyprexa block the histamine 1 receptor at around the very strong level of -. Risperdal blocks it at a lesser 19. The smaller number indicates the greater the blockage.
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