How to give a haldol decanoate injection

In pharmacokinetic studies, mild to moderately increased haloperidol concentrations have been reported when haloperidol was given concomitantly with drugs characterized as substrates or inhibitors of CYP3A4 or CYP2D6 isoenzymes, such as itraconazole, nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, and promethazine.

When prolonged treatment (1 to 2 weeks) with enzyme-inducing drugs such as rifampin or carbamazepine is added to haloperidol therapy, this results in a significant reduction of haloperidol plasma levels.

Rifampin
In a study of 12 schizophrenic patients coadministered oral haloperidol and rifampin, plasma haloperidol levels were decreased by a mean of 70% and mean scores on the Brief Psychiatric Rating Scale were increased from baseline. In 5 other schizophrenic patients treated with oral haloperidol and rifampin, discontinuation of rifampin produced a mean -fold increase in haloperidol concentrations.

Carbamazepine
In a study in 11 schizophrenic patients co-administered haloperidol and increasing doses of carbamazepine, haloperidol plasma concentrations decreased linearly with increasing carbamazepine concentrations.

Thus, careful monitoring of clinical status is warranted when enzyme inducing drugs such as rifampin or carbamazepine are administered or discontinued in haloperidol-treated patients. During combination treatment, the haloperidol dose should be adjusted, when necessary. After discontinuation of such drugs, it may be necessary to reduce the dosage of haloperidol.

Valproate
Sodium valproate, a drug known to inhibit glucuronidation, does not affect haloperidol plasma concentrations.

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blood in your urine.
  • Chills, sore throat, and body aches.
  • Decreased thirst.
  • Fast or uneven heartbeat.
  • Feeling very thirsty or hungry.
  • Fever, sweating, confusion, or muscle stiffness.
  • Lightheadedness or fainting.
  • Problems with vision, speech, balance, or walking.
  • Seeing or hearing things which are not there.
  • Seizures (convulsions).
  • Tremors or movements that you cannot control in the tongue, face, neck, jaw, or eyes
  • Trouble breathing or swallowing.
  • Trouble with swallowing or talking, sticking out of the tongue, or spasm of the neck muscles.
  • Unusual bleeding, bruising, or weakness.
  • Unusual facial expressions.
  • Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
  • Anxiety, drowsiness, or depression.
  • Decrease in how much or how often you urinate.
  • Dry mouth, cough, or headache.
  • Hair loss.
  • Loss of appetite.
  • Nausea, vomiting, diarrhea, or stomach upset.
  • Pain in the breast, irregular menstrual periods.
  • Skin rash, soreness, or pain at the injection site.
  • Trouble having sex or increased development of breasts (in men).
  • Trouble sleeping or restlessness.

Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms of many conditions. There are numerous cases of nausea and vomiting. Some causes may not require medical treatment, for example, motion sickness, and other causes may require medical treatment by a doctor, for example, heart attack, lung infections, bronchitis, and pneumonia.

Some causes of nausea and vomiting may be life threatening, for example, heart attack, abdominal obstruction, and cancers.

Treatment of nausea and vomiting depends upon the cause.

How to give a haldol decanoate injection

how to give a haldol decanoate injection

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