A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.
This is a common problem with pellets. If you go looking for forums on the matter, you will see that it is rather typical for patients to have a similar response somewhere around the 4th and 5th implantation. This stems from poor oversight/management, and design flaws in the pellets themselves. Keep in mind that all pellets are made the same way. This may seem beneficial at first glance, however, what this really means is that “6 months” worth of medication dissolves in a way that sends your levels far too high in the first month, and then plummeting far too fast and low in the next 2-3.
My point is, if you have severely low progesterone go to a doctor if you can and if you can’t eat healthy as possible and get some progesterone natural cream. You can and more then likely will have a stroke if you let it go too long. I just thought I wasn’t woman enough to handle the changes when I was menstruating and never told anyone, don’t ever just think it’s normal and not ask. I am trying to fix it myself (I have no insurance) but who knows if it will work or not. My period starts tomorrow so we will see.