A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.
Hello, I had Gynocomastia surgery in February 2009 which was successful until about December 2011/January 2012. I regrew my man boobs, I then had an in office procedure to trim the fat around the chest which didn’t do much of anything. I then had full on gynocomastia surgery in February 2014 which again was great until 2 days ago when now I grew a boob only on my left chest/pec. I have spent about $12,000 on surgeries and am not sure what to do. I am going back to the surgeon who did my surgery in Feb 2014 to speak with him. I am not sure if I have a hormonal problem, I did have blood test before the surgeries that indicated I did not. I lift weights and do not use steroids, I use pre workouts and protein that I buy from vitamin shoppe and they have no hormones or testosterone. I take Amino Acids, multivitamin, vitamin C, biotin. All things that are purchased at GNC or Vitamin Shoppe. Nothing illegal, any idea or suggestions on something to forever cure this ?
In a study published 1997, researchers studied testosterone and health in a sample of 4,393 men between the ages of 32 and 44 who had served in the military between 1965 and 1971. The men were interviewed and medically examined. Testosterone was measured in plasma from blood drawn at 8am. Concentrations ranged from 53 to 1,500 ng/dl with an average of 679. Comparison of men with slightly below average levels of testosterone (400ng/dl) with men with slightly above average levels (800ng/dl) revealed significant differences in health indicators.