By October 1945, DDT was available for public sale in the United States, used both as an agricultural pesticide and as a household insecticide.  Although its use was promoted by government and the agricultural industry, US scientists such as FDA pharmacologist Herbert O. Calvery expressed concern over possible hazards associated with DDT as early as 1944.    In 1947, Dr. Bradbury Robinson , a physician and nutritionist practicing in St. Louis, Michigan , warned of the dangers of using the pesticide DDT in agriculture. DDT had been researched and manufactured in St. Louis by the Michigan Chemical Corporation , later purchased by Velsicol Chemical Corporation ,  and had become an important part of the local economy.  Citing research performed by Michigan State University  in 1946, Robinson, a past president of the local Conservation Club,  opined that:
The evaluated population consisted of 39 patients in the low-dose Ferrlecit (sodium ferric gluconate complex in sucrose injection) group (50% female, 50% male; 74% white, 18% black, 5% Hispanic, 3% Asian; mean age 54 years, range 22–83 years), 44 patients in the high-dose Ferrlecit group (50% female, 48% male, 2% unknown; 75% white, 11% black, 5% Hispanic, 7% other, 2% unknown; mean age 56 years, range 20–87 years), and 25 historical control patients (68% female, 32% male; 40% white, 32% black, 20% Hispanic, 4% Asian, 4% unknown; mean age 52 years, range 25–84 years).
In 2009, the committee of scientific experts of the Stockholm Convention concluded, "endosulfan is likely, as a result of long range environmental transport, to lead to significant adverse human health and environmental effects such that global action is warranted."  In May 2011, the Stockholm Convention committee approved the recommendation for elimination of production and use of endosulfan and its isomers worldwide. This is, however, subject to certain exemptions. Overall, this will lead to its elimination from the global markets.