Fluphenazine came into use in 1959.  The injectable form is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system .  It is available as a generic medication .  In the United States the tablets costs between and USD per day for a typical dose.  The wholesale cost in the developing world of the long acting form is between and USD per injection as of 2014.  It was discontinued in Australia around mid 2017. 
Neuroleptic drugs elevate prolactin levels; the elevation persists during chronic administration. Tissue culture experiments indicate that approximately one-third of human breast cancers are prolactin dependent in vitro , a factor of potential importance if the prescription of these drugs is contemplated in a patient with a previously detected breast cancer . Although disturbances such as galactorrhea , amenorrhea , gynecomastia , and impotence have been reported, the clinical significance of elevated serum prolactin levels is unknown for most patients. An increase in mammary neoplasms has been found in rodents after chronic administration of neuroleptic drugs. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this time.
It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking fluphenazine . It will probably take several weeks to see big enough changes in your symptoms to decide if fluphenazine is the right medication for you. If you take the fluphenazine long-acting injection, it will take a few days before fluphenazine is fully absorbed and at an adequate level to begin treating your symptoms. After starting fluphenazine long-acting injection for the first time, or re-starting after a time of no medication, your provider may also have you take fluphenazine tablets for a few days.